Observations on Rapidly Reacting Hemoglobin

Some clinical, biochemical and genetic observations on hemoglobin C.

Recent observations (1, 2) in certain American Negroes, of a previously unrecognized abnormal hemoglobin, now designated as hemoglobin C,2 constitute a significant advance in knowledge of familial anemias. The introduction of filter paper electrophoresis (3, 4) for identification of abnormal hemoglobins (5, 6) has facilitated the study of specimens of hemoglobin from a large number of subjects....

Observations on the inheritance of sickle-cell hemoglobin and hemoglobin C.

The reaction of cytochrome oxidase with cyanide. Preparation of the rapidly reacting form and its conversion to the slowly reacting form.

The magnitude of the slow phase of reaction of cytochrome oxidase with cyanide has been correlated with the size of the epr signal at g' = 12. This epr signal was not found in submitochondrial particles, and significant g' = 12 epr was only observed late in the purification of solubilized enzyme. The Hartzell-Beinert procedure for the purification of cytochrome oxidase (Hartzell, C.R., and Bein...

Studies on the Coagulase-reacting Factor

Among the diverse views which have been advanced to explain the mechanism of the clotting of blood by staphylocoagulase, it has been suggested that coagulase acts directly on fibrinogen,4"3 or that it is a proteolytic enzyme,3 similar to trypsin, which activates prothrombin. Recently, however, the enzymic nature ofcoagulase has been questioned.12 Smith and Hale,' in a significant contribution, ...

On the Theory of Chemically Reacting Gas

The method to determine the molecular velocity distribution in steady reaction in homogeneous gas phase with negligible reaction heat is formulated, and especially the case where one of the reacting molecules is very light is studied in detail. In this case the perturbation of the distribution function by the chemical reaction becomes most remarkable, and the expansion by the Sonine's polynomia...